COX-2 has been reported to be induced in the heart during I/R [45] and its expression was positively associated with the expression of HIF-1α at the site of recent acute myocardial infarction [46], despite the fact that direct evidence regarding whether or not COX-2 was transcriptionally controlled by HIF-1α in cardiomyocytes is lacking. Here, HIF1A is linked to acute myocardial infarction.