Deficiency of hypoxia inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1) in the mice significantly attenuated MI/R injury through reduced apoptosis by induction of HIF-1α [49], and COX-2 serves a protective role against myocardial I/R injury [50, 51]. The gene discussed is HIF1A; the disease is myocardial infarction.