It is important to note that studies of anti-GITR in tumor models vary in the isotype of anti-GITR mAb used—those that treat with a rat IgG2b mAb would expect to see some T cell depletion as they share the isotype with a number of in vivo depleting mAbs (i.e., GK1.5, YTS191, YTS169, etc.), and those testing an anti-GITR mouse IgG2a should expect to see ADCC pathway cell depletion mediated by FcγR interactions [14, 26]. The gene discussed is TNFRSF18; the disease is neoplasm.