NFKBIA and sexually transmitted disease: In this acute STI model, an activated inflammatory signaling pathway was exhibited with downregulated IκBα expression in the cytosol, indicating that IκBα was degraded in the cytosol, upregulated expression of NF-κB p65 mRNA, and downregulated in the cytosol and upregulated in the nuclei NF-κB p65 expression, indicating that NF-κB p65 synthesis was enhanced and that more NF-κB p65 was translocated to the nucleus.