GPT and Hepatic fibrosis: There are many researches indicating that, in both rat and mouse models of liver disease, Yiguanjian could reduce liver fibrosis [22–26], and oral administration of Yiguanjian decoction significantly reduced the serum aspartate aminotransferase (AST) and alanine transaminase (ALT) and inhibited accumulation of collagen I, tissue inhibitor of metalloproteinase-1, and α-smooth muscle actin (α-SMA) in hepatic tissues.