VEGFA and lung adenocarcinoma: Schizandrin B, one of the main dibenzocyclooctadiene lignans present in Schisandrae Fructus, was also shown to have an anticancer effect by blocking the invasion and migration of lung adenocarcinoma A549 cells through downregulation of expression of HIF-1, VEGF, and matrix metalloproteinase (MMP) [25].