CASP1 and hyperlipidemia: Yin et al. [48] demonstrated for the first time that early hyperlipidemia promotes endothelial cells (EC) activation before monocyte recruitment via a caspase-1-sirtuin 1-activator protein-1 pathway, which provides an important insight into the development of novel therapeutics for blocking caspase-1 activation as early intervention of metabolic cardiovascular diseases and inflammations.