FANCD2 and cancer: We also observed that FA deficiency marginally increased the disease severity (for Bi-L E7/K14–tTA/FancD2+/+ versus Bi-L E7/K14-tTA/FancD2−/−, P = 0.11) while greatly increasing the incidence of cancers (for Bi-L E7/K14–tTA/FancD2+/+ versus Bi-L E7/K14-tTA/FancD2−/−, P = 0.0026).