FANCD2 and cancer: In contrast, the difference in the overall severities of disease when E7 was turned off in the FancD2-sufficient background was highly significant (for Bi-L E7/K14–tTA/FancD2+/+ versus Bi-L E7/K14–tTA/FancD2+/+ [Dox], P = 2.644 × 10−6; P = 7.9 × 10−6 if we exclude cancers).