Turning off expression of E7 led to only marginal regression of overall disease severity in the study of the lower reproductive tract (for Bi-L E7/K14-tTA/FancD2−/− versus Bi-L E7/K14-tTA/FancD2−/− [Dox], P = 0.08; P = 0.16 if we exclude cancers). Here, KRT14 is linked to cancer.