In mutant SOD1 mouse models of ALS, activation of the PERK branch appears to mediate a pro-survival response (Saxena et al., 2009; Das et al., 2015), similarly in a A53T alpha-synuclein mutation model of Parkinson’s disease (Colla et al., 2012). This evidence concerns the gene EIF2AK3 and amyotrophic lateral sclerosis.