EIF2AK3 and Wolcott-Rallison syndrome: Similar phenomena are also seen in PERK-deficient mice (Harding et al., 2001) and in the rare human disorder Wolcott-Rallison syndrome, which presents with neonatal diabetes due to loss-of-function mutations in the PERK gene EIF2AK3 (Julier and Nicolino, 2010).