The advent of tau-ligand PET imaging has further corroborated this picture, showing that pathological interactions of tau and amyloid can better explain disease progression and symptomology in Alzheimer’s disease than either individual pathology (Khanet al., 2014).Khan and colleagues (2014) also showed that tau-amyloid interaction not only affected the entorhinal cortex but also influenced its connectivity to the parietal cortex and, thus potentially, posterior cingulate and retrosplenial areas. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.