To mimic the ectopic expression of ABHD5 in TAMs and to investigate its role in CRC cell growth in vivo, we created a CD11b promoter-driven myeloid-cell-specific ABHD5 transgenic (TgABHD5) mouse model (Supplementary Fig. 2a), in which the CRC cells were inoculated subcutaneously. The gene discussed is ITGAM; the disease is colorectal carcinoma.