Production of interferon-γ, tumour necrosis factor-α, interleukin-1β and interleukin-6 was used as a read-out.<h4>Results</h4>In asymptomatic subjects, HIV infection was associated with reduced interferon-γ, release after stimulation and priming of the pro-inflammatory cytokine response to non-typhoidal <i>Salmonella</i>. Here, IL6 is linked to HIV infectious disease.