Willipinski et al. [92] utilised a large series (>2200) of breast cancers to demonstrate that loss of CK and ectopic vimentin expression were significantly associated with a higher tumour grade, high mitotic index, and negative oestrogen/progesterone receptor (ER/PgR) status, and significantly related to clinical outcome in univariate analyses. Here, ESR1 is linked to neoplasm.