SOX9 and campomelic dysplasia: For example, Sox9, which is induced by 55.1 folds in SO vs 2D and 50.4 in SO vs 8D, is a HMG-box class transcription factor and a master regulator of the pancreatic program, liver progenitors, duodenal development, chondrogenesis, sex determination, Sertoli cell differentiation during testis development, craniofacial development and is mutated in campomelic dysplasia, a disorder characterized by skeletal malformations, XY sex reversal, and neonatal lethality20, 21, 22.