RUNX1 and leukemia: Runx1, which is induced by 5.1 folds in SO vs 2D and 18.2 in SO vs 8D, is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters, with important regulatory functions in hematopoietic stem/progenitor cells and causal roles in human leukemias as well as solid tumors23, 24.