For example, HULC (Highly Upregulated in Liver Cancer) is expressed at high levels in HCC and colorectal carcinomas that have metastasized to the liver [39, 40], but not in primary colon tumors or non-liver metastases, with increased plasma HULC levels observed in 63 % of HCC patients [41]. This evidence concerns the gene HULC and colorectal carcinoma.