Immunostaining of serial left main coronary artery sections for SM α‐actin and SM‐MHC revealed decreased expression of these contractile SMC markers in the media of arteries from patients with moderate and severe coronary atherosclerosis compared to patients with no/mild disease (Fig 4C and D), consistent with previous findings (Glukhova et al, 1988; Aikawa et al, 1993, 1995). The gene discussed is MYH11; the disease is coronary atherosclerosis.