They confirmed signals in the LPA and PCSK9 genes but also identified novel variants in genes thus far not associated with CAD: a missense variant in the ANGPTL4 gene and a missense variant in the sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 gene (SVEP1). This evidence concerns the gene ANGPTL4 and coronary artery disorder.