TCF7L2 and type 2 diabetes mellitus: Large-scale trans-ethnic meta-analyses have also demonstrated that many T2D GWAS loci are shared across diverse populations and that the allelic effects of lead SNPs at common variant association signals are predominantly homogeneous across ancestry groups.26 Amongst lead SNPs at loci attaining genome-wide significance in our multi-ethnic analysis, we detected nominal evidence of interaction with the first two AGV only at TCF7L2, where a smaller allelic effect on T2D susceptibility in individuals of East Asian ancestry was observed than in other ethnic groups.