Curiously, we observed that the TLR4-mediated cytokine response by CD4+ T cells was unaltered in CVID patients (data not shown), whereas intracellular TLR3/Poly-RIG activation led to decreased IFN-γ, IL-17a and IL-22 responses by CD8+ T cells but not CD4+ T cells. Here, TLR4 is linked to common variable immunodeficiency.