Notably, the amount of IL-17A-producing MOG35–55-activated CD4+CD40 ligand (CD40L)+ T cells obtained from draining LN was reduced in F12−/− mice, as compared with WT animals, while the number of IFN-γ-producing CD4+CD40L+ T cells was unaltered, suggesting that antigen-specific sensitization and priming of TH17 cells is impaired in FXII deficiency (Supplementary Fig. 3). Here, CD4 is linked to hyperinsulinemic hypoglycemia, familial, 4.