Importantly, SOX7 expression was correlated positively with AXIN2 (rs = 0.379, p = 0.001) and negatively with β-catenin (rs = −0.317, p = 0.006) and pivotal hub or downstream genes in the Wnt-β-catenin pathway, strongly suggesting a possible role of SOX7 as a negative regulator by down-regulating β-catenin and AXIN2 as a co-regulator through the Wnt-β-catenin pathway in breast cancer. The gene discussed is AXIN2; the disease is breast carcinoma.