In phase 2 studies of BIL in which patients had all been on insulin prior to randomization to BIL versus IG, BIL-treated patients had an increase from baseline of serum TG, while IG-treated patients did not [least squares mean (LSM) difference for type 1 diabetes: 29 mg/dL; for type 2 diabetes: 27 mg/dL] [31, 41]. Here, INS is linked to type 1 diabetes mellitus.