Overall, BIL was quite consistently associated with reduced risk for nocturnal hypoglycemia [45]; total hypoglycemia was comparable in patients who were treated with basal insulin only; in patients on basal-bolus insulin therapy, there was an increase in daytime hypoglycemia as well as total hypoglycemia with BIL [25, 26, 28]. The gene discussed is INS; the disease is Hypoglycemia.