For the Han population, the IHC analysis displayed that the frequency of PFN2 protein overexpression was lowest in the NEE tissue (8.1 %), but its frequency increased gradually along with the progress of esophageal cancer, with 40.4 % (21/52) of LGIN and 91.0 % (30/33) of HGIN. Here, PFN2 is linked to esophageal cancer.