TCF7L2 and type 2 diabetes mellitus: Most notably, having any copy of the T allele for rs7903146 (a common variant in TCF7L2 candidate gene for type 2 diabetes) conferred increased risk of multiple-vessel obstructive lesions, greater burden of atherosclerotic disease, and increased incidence of death among 889 subjects referred for cardiac catheterization and 559 MASS-II trial participants followed prospectively over 5 years [30].