Based upon our in vitro results, we propose that a subset of colorectal cancers (CRCs) with mutations in V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and Wingless/Integrated (WNT)/beta-catenin signaling might be most sensitive to the effects of hyperthermia as an anti-cancer therapy. Here, KRAS is linked to cancer.