More significantly, in human CRC tissue SMOC2 was preferentially localized in the more invasive areas of the tumor (Figure 5B) and exclusively at the bottom of colonic crypts of normal colonic epithelium, most probably in the stem cell compartment, as also observed in the Lgr5+ containing stem cells of the mouse intestine [51]. The gene discussed is LGR5; the disease is colorectal carcinoma.