Focusing on one of these genes, SMOC2 (secreted, modular, matricellular, Ca2+-binding protein 2), we found that the expression of SMOC2 is induced by an L1-ezrin-NF-κB mechanism and that SMOC2 is necessary for the L1-mediated increase in cell motility and the metastasis of CRC cells [51]. The gene discussed is NFKB1; the disease is colorectal carcinoma.