Our results demonstrated that IP6 and Ins inhibited the development of CRC metastasis to the murine liver by altering expression of the ECM proteins collagen IV, FN and LN, the adhesion factor receptor integrin-β1, the proteolytic enzyme MMP-9, and the angiogenic factors VEGF, bFGF, and TGF-β in the tumor metastasis microenvironment. The gene discussed is VEGFA; the disease is neoplasm.