The mRNA expression levels of collagen IV, LN, FN, integrin-β1, MMP-9, VEGF, bFGF, and TGF-β were measured by real-time PCR to further characterize the mechanism by which CRC metastasizes to the liver and to determine whether IP6, Ins or their combination prevents the metastasis of CRC to the liver. This evidence concerns the gene INS and colorectal carcinoma.