IGF2 and Glucose intolerance: A recent study demonstrated that exposure to BPA in early life induces glucose intolerance and β-cell dysfunction, with hypermethylation and associated decreased expression of IGF2 in the islets of male F2 offspring; this finding suggests that BPA exposure during early life can result in generational transmission of glucose intolerance and β-cell dysfunction through the male germ line by an epigenetic mechanism [102].