MDM2 and breast carcinoma: However, the compounds did not show selectivity between breast cancer cell lines with wt p53 (MCF-7) and mut p53 (MDA-MB-231), and although an increase in MDM2 levels was observed, no studies were focused in the p53-MDM2 interaction (38, MTT MCF-7 IC50 = 6.5 μM, Figure 10).