The 725-oncogene depth targeted sequencing revealed four confirmed base-substitution somatic mutations in NOTCH2, NSD1, PDE4DIP, and ATP10B and one verified 4-base insert frameshift somatic mutation in BAP1. According to the results of the functional prediction, the mutations in BAP1, NOTCH2 and NSD1 were the most possible driver somatic mutations in the development of MM in our patient. Here, NSD1 is linked to Miyoshi myopathy.