Some other mRNA targets of miR-221 were highlighted by Sarkar S et al. [54] revealing that the inhibition of miR-221 could decrease the proliferative capacity of the pancreatic cancer cells by rescuing the tumor suppressor activity of PTEN, p27kip1, p57kip2 (cyclin-dependent kinase inhibitor 1C), and PUMA (p53 upregulated modulator of apoptosis), which are well-known tumor suppressors. This evidence concerns the gene PTEN and neoplasm.