Overall, miR-375 is involved in the suppression of core hallmarks of cancer, such as cell growth, invasion, migration, metastasis and proliferation, by targeting several important oncogenes like AEG-1 (astrocyte elevated gene-1), YAP1 (yes-associated protein 1), IGFR1 and PDPK1 (3-phosphoinositide-dependent protein kinase 1), thus making it an encouraging target in many antitumor strategies [105]. The gene discussed is PDPK1; the disease is cancer.