TGFB1 and neoplasm: On the contrary, “M2-macrophages” or “wound-healing/resolution macrophages” secrete a variety of growth factors, like EGF, FGF and VEGF, and immunosuppressive factors including IL-10, PGE2 and TGF-β, thus providing a tumor-friendly micromilieu concomitant with a much worse prognosis for the afflicted patients [41,43,44,45].