Three distinct MAPKs family members including extracellular signal-regulated kinase 1 and 2 (ERK1/2), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK), and p38 play a major role in tumor progression and metastasis by inducing proteolytic enzymes that degrade the basement membrane, enhances cell migration [27,28]. Here, MAPK3 is linked to neoplasm.