ATG5 and cancer: The mechanisms behind the anticancer effects of ITCs are not fully understood, but known responses to these natural products in in vivo assays include: (i) prevention of cancer development in animal models [12,65,99,146,147,148,149,150,151,152,154,155,156,157,158,159,160,161]; (ii) suppression of cancer cell viability in association with apoptosis induction [12,148,152,155] and Atg5-dependent autophagic cell death [12,157]; (iii) inhibition of metastasis [12,147,151,152]; (iv) inhibition of angiogenesis [12,147,148].