SFN (20 μM) induces p53 [55] and p21 in LNCaP cancer cells [55,88], but the induction of p21 seems to be independent of p53, since it occurs in the absence of the induction of p53 and Ser15 phosphorylation, and it is probably associated with the inhibition of HDAC activity. The gene discussed is TP53; the disease is cancer.