BDNF and Behcet disease: Several explanations could be responsible for the observed effects and changes in availability of monoamines and endorphins, exercise-induced inflammatory response, reversal of oxidative stress, BDNF, epigenetics, neuroplasticity and cellular resilience are all widely discussed pathways for putative post-exercise change in BD symptomology.8, 9, 10, 11, 12 Based on regions and timing of response some mechanisms may be more likely than others.