Potential physiological mechanisms of exercise-related reduction of cognitive symptoms in BD include availability of monoamines and endorphins, exercise-induced inflammatory response, reversal of oxidative stress, BDNF, epigenetics, neuroplasticity and cellular resilience.8, 9, 10, 11, 12, 26 Studies demonstrating exercise effects on neurocognitive function in BD have been slow to emerge,11, 12 however, there is a developing literature establishing improvement of neurocognitive function with long-term exercise in schizophrenia27, 28 and depression,29 and chronic and acute exercise in ADHD.30 The gene discussed is BDNF; the disease is Behcet disease.