The role of the NADPH oxidase NOX2 in human pathologies has been well documented, ranging from chronic granulomatous disease,23, 24, 25 acute myocardial infarction26 to neurodegenerative disorders.8 However, concerning the role of NOX2 in the pathogenesis of psychiatric disorders, all available data have been obtained in animal or cellular models. The gene discussed is FMO5; the disease is chronic granulomatous disease.