CYBB and psychotic disorder: This enzyme is constitutively expressed in the CNS and is a major generator of ROS in several pathological conditions, from psychiatric to neurodegenerative diseases.8 In particular, we recently demonstrated that early NOX2 increase in specific brain areas contributes to the development of neuropathological alterations observed in non-pharmacologic and pharmacologic rodent models of psychosis, such as the social isolation and the ketamine model, respectively.9, 10, 11