Multiple studies have shown that high circulating interleukin-6 (IL-6) is positively associated with enhanced risk of disease and disability development.12 In particular, cerebral IL-6 expression has been shown to mediate alterations of CNS functioning, including modulation of glutamatergic neurotransmission.13 In the ketamine rodent model of psychosis, administration of this dissociative anaesthetic drug to young mice increased expression of IL-6 in the brain, as well as of the NADPH oxidase NOX2 (ref. 14). Here, CYBB is linked to psychotic disorder.