The endocannabinoid system, including cannabinoid receptor-1 (CB1) and its endogenous endocannabinoid ligands, anandamide and 2-arachidonoylglycerol (2-AG), is an important modulator of dorsal striatal neuroplasticity and has known involvement in fear processing and PTSD diagnoses. Here, CNR1 is linked to post-traumatic stress disorder.