Nuclear ERβ2 isoform was reported to have an oncogenic role due to its ability to increase proliferation and expression of twist family bHLH transcription factor 1 (Twist1) and v-myc avian myelocytomatosis viral oncogene homolog (c-Myc) in PC3 and 22Rv1 carcinoma human prostate cancer cell lines (Dey et al. 2012). This evidence concerns the gene TWIST1 and Familial prostate cancer.