ESR2 and prostate carcinoma: Endogenous activation of ERβ in PC3 and DU-145 (prostate carcinoma derived from metastatic site—brain) cells was reported to cause an increase in cyclin-dependent kinase inhibitor 1A (p21) expression and cell cycle arrest indicating that control of proliferation might be governed by cell cycle modulation (Colciago et al. 2014).