HIF1A and Familial prostate cancer: It was suggested that on the molecular level only ERα and epidermal growth factor receptor (EGFR) expression correlates with the levels of all proinflammatory molecules, and HIF1-α and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) are the master regulators of hypoxia and inflammation, respectively, in prostate cancer cell lines (Ravenna et al. 2009, 2014).