In addition, there was a significant interaction between total fat intake and MC4R SNPs in relation to abdominal obesity (P interaction = 0.01), i.e., in A allele carriers, the risk of abdominal obesity increased across quartiles of total fat intake (P trend = 0.005), however the association was not significant in GG homozygote carriers (P trend = 0.41) (Fig. 1). This evidence concerns the gene MC4R and Abdominal obesity.