The interaction between genotypes of rs17782313 MC4R and nutrient intakes in relation to phenotypes related to obesity has only been examined in a few cross-sectional studies [10]; hence to gain more insight into the etiology of MetS and finding a diet tailored to the genetic makeup of patients with MetS, the effect of interaction between MC4R rs12970134 with dietary patterns, nutrients (macronutrients, Iron, zinc and magnesium) or food groups on the risk of MetS and related components were investigated in this nested case-control study. Here, MC4R is linked to obesity due to melanocortin 4 receptor deficiency.