COX5A and Hyperglycemia: In contrast, disruption of ETC Complex IV in the IPCs (Cox5a RNAi) failed to produce hyperglycemia, while RNAi in the fat body caused lethality prior to adulthood, similar to ATPsynβ. This premature lethality was accompanied by severe developmental delay and more than 50% of the animals dying prior to puparium formation when raised on the 15% sugar diet.