On the transcriptional level, we showed that a large set of lipogenic TFs and enzymes were significantly up-regulated following the deletion of Smo. Among the responding TFs were Srebf1, Ppara and Pparg strongly increased which are characteristic for liver steatosis (Fabbrini et al., 2010; Ables, 2012). This evidence concerns the gene SREBF1 and Hepatic steatosis.