HNF1A and type 2 diabetes mellitus: Our results showed reduction of diabetic signature through multiple gene sets, which includes the upregulation of the repressed genes in pancreatic islet upon HNF1A knockout (Servitja islet HNF1A targets dn, Table 1) and downregulation of type I and type II diabetic genes (KEGG Type I diabetes mellitus, GSE9006 healthy Vs type 2 diabetes, Table 1).