The genome-wide significant SNPs tended to be in or near well-known or highly plausible disease-relevant genes, such as IL1RL1 (rs2160203) in allergic rhinitis (Li et al. 2015), HLA-DQB1 (rs17612802; 6.9 kb distant) in asthma (Li et al. 2010), TCF7L2 (rs4506565) in type 2 diabetes (Zeggini and McCarthy 2007), APOB (rs1367117) in dyslipidemia (Di Taranto et al. 2015), and KCNK3 (rs1275985) in hypertensive disease (Girerd et al. 2014). This evidence concerns the gene HLA-DQB1 and metabolic syndrome.