The genome-wide significant SNPs tended to be in or near well-known or highly plausible disease-relevant genes, such as IL1RL1 (rs2160203) in allergic rhinitis (Li et al. 2015), HLA-DQB1 (rs17612802; 6.9 kb distant) in asthma (Li et al. 2010), TCF7L2 (rs4506565) in type 2 diabetes (Zeggini and McCarthy 2007), APOB (rs1367117) in dyslipidemia (Di Taranto et al. 2015), and KCNK3 (rs1275985) in hypertensive disease (Girerd et al. 2014). This evidence concerns the gene TCF7L2 and asthma.