More recent studies showed that leptin induced expressions of Notch1, 3, 4 in breast cancer cells, and inhibition of leptin signaling, led to decreased protein expression levels of NICD1, NICD4, Notch3, JAG1 and survivin as well as reduced mRNA levels of Notch receptors, ligands and targets (Battle et al., 2014). The gene discussed is NOTCH3; the disease is breast cancer.