LEP and esophageal adenocarcinoma: Leptin represented anti-apoptotic activities in many human cancer cells including Barrett's esophageal adenocarcinoma cells, colon cancer cells, and breast cancer cells (Jardé et al., 2011; Ogunwobi et al., 2006; Ogunwobi and Beales, 2007; Rouet-Benzineb et al., 2004).