The present study identified a distinct altered FC pattern associated with cognitive impairment and a selective topography of functional changes in the MTL subregional networks, indicated that the disruption of the right HIP–ERC–PRC–temporal pathway was responsible for the impairment of episodic memory, and provided new insights to understand the pathophysiology underlying the memory deficits in aMCI. This evidence concerns the gene PPRC1 and Cognitive impairment.