Components of the ECM, like fibronectin and tenascin and the latency‐associated peptide 1 and 3 have been shown to activate αvβ6 integrin leading to local activation of TGFβ1 signaling at tumor‐stroma interface facilitating tumor migration and invasion 14, 15, 16, 17. Here, TGFB1 is linked to neoplasm.