YAP1 and neoplasm: To test whether the different functions of TAZ and YAP can be explained by different transcriptional activities, we used a panel of Hippo signalling reporters (see supplementary material, Table S2), including the 8XGTIIC Hippo 41, 42, CTGF (connective tissue growth factor; a Hippo reporter with three Tead binding sites from this gene 32) and a Brachyury reporter (as YAP has been reported to bind TBX5 in tumour cell lines 8).