NRG1 and fibrosis: On the other hand, a significant effect on tissue remodeling was not detected in animals treated with FGF1-MPs (% Fibrosis: Control-MPs: 40.9 ± 2.8%, NRG1-MPs: 26.2 ± 4.5%; P < 0.05, FGF1-MPs: 41.8 ± 6.6%,) (Fig. 6B).