ACE and infection: Unlike our review, O’Donoghue and colleagues had access to individual patient data from three studies (PEACE – Prevention of Events with Angiotensin Converting Enzyme Inhibition; [83] CARE - Cholesterol and Recurrent Event); [84] and PROVE IT–TIMI 22 - Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis In Myocardial Infarction 22 [85] trials) and were able to pool these data.