Compared to the previous report by Coriat et al. presenting a first clinical analysis centred on the measurement of serum levels of AOPP [4], our study brings three important additional pieces of information: i) Firstly, the measurement of MT1 provides a more specific and standardizable analysis for the study of the effects of sorafenib on the redox metabolism of cancer cells than AOPP; ii) Secondly, our study highlights the existence of important individual heterogeneity in terms of the ability of sorafenib to activate the transcription of the MT1 genes. This evidence concerns the gene MT1A and cancer.