MT1A and cancer: In order to explore the possibility that oxidative stress might play a role in the overexpression of MT1 induced by sorafenib, Huh7 cells were treated with deferoxamine (DFX), an iron chelator reported to protect cancer cells from oxidative stress and ferroptosis by preventing the formation of potent oxidants [5, 10] before being exposed to sorafenib (Fig. 2a).