SERPINA1 and neurodegenerative disease: SerpinA1 is closely homologous to neuroserpin25 another serpin family member and it is very interesting that the histochemistry of serpinA1 aggregates is very similar to inclusions found in neurodegenerative disease caused by intracellular accumulation of mutant neuroserpin; familial encephalopathy with neuroserpin inclusion bodies26.